Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science

K Inamura, T Hamada, S Bullman, T Ugai, S Yachida… - Gut, 2022 - gut.bmj.com
Cancer is generally regarded as a localised disease, with the well-established role of the
tumour microenvironment. However, the realm of cancer goes beyond the tumour …

[HTML][HTML] Population-level metagenomics uncovers distinct effects of multiple medications on the human gut microbiome

N Nagata, S Nishijima, T Miyoshi-Akiyama, Y Kojima… - Gastroenterology, 2022 - Elsevier
Background & aims Medication is a major determinant of human gut microbiome structure,
and its overuse increases the risks of morbidity and mortality. However, effects of certain …

Performance of gut microbiome as an Independent Diagnostic Tool for 20 Diseases: Cross-cohort Validation of Machine-Learning classifiers

M Li, J Liu, J Zhu, H Wang, C Sun, NL Gao… - Gut …, 2023 - Taylor & Francis
Cross-cohort validation is essential for gut-microbiome-based disease stratification but was
only performed for limited diseases. Here, we systematically evaluated the cross-cohort …

Predicting personalized responses to dietary fiber interventions: opportunities for modulation of the gut microbiome to improve health

CR Kok, D Rose, R Hutkins - Annual Review of Food Science …, 2023 - annualreviews.org
Inadequate dietary fiber consumption has become common across industrialized nations,
accompanied by changes in gut microbial composition and a dramatic increase in chronic …

The role of the microbiome in pancreatic cancer

K Miyabayashi, H Ijichi, M Fujishiro - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic cancer is deadly cancer characterized by dense stroma
creating an immunosuppressive tumor microenvironment. Accumulating evidences indicate …

Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets

JH Dai, XR Tan, H Qiao, N Liu - Protein & Cell, 2024 - academic.oup.com
The profound influence of microbiota in cancer initiation and progression has been under
the spotlight for years, leading to numerous researches on cancer microbiome entering …

Depletion of butyrate-producing microbes of the Firmicutes predicts nonresponse to FMT therapy in patients with recurrent Clostridium difficile infection

H Tian, J Cui, C Ye, J Zhao, B Yang, Y Xu, S Ji… - Gut …, 2023 - Taylor & Francis
Approximately 10% of individuals diagnosed with Clostridium difficile infection (CDI) show
the resistance to fecal microbiota transplantation (FMT), with the underlying mechanisms …

Changes in intestinal bacteria and imbalances of metabolites induced in the intestines of pancreatic ductal adenocarcinoma patients in a Japanese population: a …

S Hashimoto, T Tochio, K Funasaka… - Scandinavian Journal …, 2023 - Taylor & Francis
Background The relationship between pancreatic ductal adenocarcinoma (PDAC) and the
intestinal environment is not fully understood. The purpose of this study was to elucidate the …

Association between Residential Greenness and Human Microbiota: Evidence from Multiple Countries

YD Zhang, SJ Fan, Z Zhang, JX Li, XX Liu… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Greenness, referring to a measurement of the density of vegetated land (eg,
gardens, parks, grasslands), has been linked with many human health outcomes. However …