Cutting through the noise: Noise-induced cochlear synaptopathy and individual differences in speech understanding among listeners with normal audiograms

M DiNino, LL Holt, BG Shinn-Cunningham - Ear and hearing, 2022 - journals.lww.com
Following a conversation in a crowded restaurant or at a lively party poses immense
perceptual challenges for some individuals with normal hearing thresholds. A number of …

Auditory brainstem measures predict reading and speech-in-noise perception in school-aged children

J Hornickel, B Chandrasekaran, S Zecker… - Behavioural brain …, 2011 - Elsevier
Reading and speech-in-noise perception, fundamental aspects of human communication,
have been linked to neural indices of auditory brainstem function. However, how these …

[HTML][HTML] Mice lacking the alpha9 subunit of the nicotinic acetylcholine receptor exhibit deficits in frequency difference limens and sound localization

A Clause, AM Lauer, K Kandler - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Sound processing in the cochlea is modulated by cholinergic efferent axons arising from
medial olivocochlear neurons in the brainstem. These axons contact outer hair cells in the …

Selective agonists and antagonists of α9 versus α7 nicotinic acetylcholine receptors

RL Papke, H Andleeb, C Stokes, M Quadri… - ACS chemical …, 2022 - ACS Publications
Nicotinic acetylcholine receptors containing α9 subunits are essential for the auditory
function and have been implicated, along with α7-containing nicotinic receptors, as potential …

Contralateral suppression of transient evoked otoacoustic emissions in children with auditory processing disorder

SGG Sanches, RM Carvallo - Audiology and Neurotology, 2006 - karger.com
This study concerns contralateral white noise suppression of transient evoked otoacoustic
emissions (TEOAEs) in children with auditory processing disorder (APD). Fifty-one children …

A computer model of auditory efferent suppression: implications for the recognition of speech in noise

GJ Brown, RT Ferry, R Meddis - The Journal of the Acoustical Society …, 2010 - pubs.aip.org
The neural mechanisms underlying the ability of human listeners to recognize speech in the
presence of background noise are still imperfectly understood. However, there is mounting …

Physiology of the medial and lateral olivocochlear systems

JJ Guinan - Auditory and vestibular efferents, 2011 - Springer
In this chapter we deal with the ways in which the two olivocochlear (OC) efferent systems,
the medial (MOC) and lateral (LOC) systems, change the operation of the cochlea and how …

Reflex control of the human inner ear: a half-octave offset in medial efferent feedback that is consistent with an efferent role in the control of masking

W Lilaonitkul, JJ Guinan Jr - Journal of neurophysiology, 2009 - journals.physiology.org
The high sensitivity and frequency selectivity of the mammalian cochlea is due to
amplification produced by outer hair cells (OHCs) and controlled by medial olivocochlear …

[HTML][HTML] Measurement of the distribution of medial olivocochlear acoustic reflex strengths across normal-hearing individuals via otoacoustic emissions

BC Backus, JJ Guinan - Journal of the Association for Research in …, 2007 - Springer
A clinical test for the strength of the medial olivocochlear reflex (MOCR) might be valuable
as a predictor of individuals at risk for acoustic trauma or for explaining why some people …

The role of the medial olivocochlear reflex in psychophysical masking and intensity resolution in humans: a review

SG Jennings - Journal of Neurophysiology, 2021 - journals.physiology.org
This review addresses the putative role of the medial olivocochlear (MOC) reflex in
psychophysical masking and intensity resolution in humans. A framework for interpreting …