Analysis and visualization of quantitative proteomics data using FragPipe-Analyst
The FragPipe computational proteomics platform is gaining widespread popularity among
the proteomics research community because of its fast processing speed and user-friendly …
the proteomics research community because of its fast processing speed and user-friendly …
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker
MT Mackmull, L Nagel, F Sesterhenn… - Nature structural & …, 2022 - nature.com
Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust
biomarkers are needed. Because protein structure reflects function, we tested whether …
biomarkers are needed. Because protein structure reflects function, we tested whether …
MS-DAP platform for downstream data analysis of label-free proteomics uncovers optimal workflows in benchmark data sets and increased sensitivity in analysis of …
F Koopmans, KW Li, RV Klaassen… - Journal of Proteome …, 2022 - ACS Publications
In the rapidly moving proteomics field, a diverse patchwork of data analysis pipelines and
algorithms for data normalization and differential expression analysis is used by the …
algorithms for data normalization and differential expression analysis is used by the …
Systematic identification of 20S proteasome substrates
M Pepelnjak, R Rogawski, G Arkind… - Molecular Systems …, 2024 - embopress.org
For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S
proteasome pathway. However, it is now evident that the core 20S proteasome can …
proteasome pathway. However, it is now evident that the core 20S proteasome can …
In situ analysis of osmolyte mechanisms of proteome thermal stabilization
M Pepelnjak, B Velten, N Näpflin, T von Rosen… - Nature Chemical …, 2024 - nature.com
Organisms use organic molecules called osmolytes to adapt to environmental conditions. In
vitro studies indicate that osmolytes thermally stabilize proteins, but mechanisms are …
vitro studies indicate that osmolytes thermally stabilize proteins, but mechanisms are …
prolfqua: A Comprehensive R-Package for Proteomics Differential Expression Analysis
Mass spectrometry is widely used for quantitative proteomics studies, relative protein
quantification, and differential expression analysis of proteins. There is a large variety of …
quantification, and differential expression analysis of proteins. There is a large variety of …
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
In myelinating Schwann cells, connection between myelin layers is mediated by gap
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …
A chemical probe to modulate human GID4 Pro/N-degron interactions
The C-terminal to LisH (CTLH) complex is a ubiquitin ligase complex that recognizes
substrates with Pro/N-degrons via its substrate receptor Glucose-Induced Degradation 4 …
substrates with Pro/N-degrons via its substrate receptor Glucose-Induced Degradation 4 …
Comprehensive overview of bottom-up proteomics using mass spectrometry
Proteomics is the large scale study of protein structure and function from biological systems
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …
represents an ever‐expanding focus in the development of proteomics. As mass …