4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Brugada syndrome (BrS) is an “inherited” condition characterized by predisposition to
syncope and cardiac arrest, predominantly during sleep. The prevalence is∼ 1: 2,000, and …

Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular
fibrillation (iVF) have long been considered primary electrical disorders associated with …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …

Failure of the right ventricle plays a critical role in any type of heart failure. However, the
mechanism remains unclear, and there is no specific therapy. Here, we show that the right …

Brugada syndrome (BrS) is an inherited cardiac disorder, characterised by a typical ECG
pattern and an increased risk of arrhythmias and sudden cardiac death (SCD). BrS is a …

The diagnosis of Brugada syndrome (BrS) requires the presence of a coved (Type 1) ST
segment elevation in the right precordial leads of the electrocardiogram (ECG). The dynamic …

Background Two major forms of inherited J-wave syndrome (JWS) are recognized: early
repolarization syndrome (ERS) and Brugada syndrome (BrS). Objectives This study sought …

Background Electrophysiological, imaging, and pathological studies have reported the
presence of subtle structural abnormalities in hearts from patients with Brugada syndrome …