Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)
HT Abdel-Mohsen, MM Anwar, NS Ahmed… - Molecules, 2024 - mdpi.com
Cancer is a complicated, multifaceted disease that can impact any organ in the body.
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma
In the current study, a series of benzimidazole-oxindole conjugates 8a-t were designed and
synthesized as type II multi-kinase inhibitors. They exhibited moderate to potent inhibitory …
synthesized as type II multi-kinase inhibitors. They exhibited moderate to potent inhibitory …
Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors
HT Abdel-Mohsen, MA Ibrahim, AM Nageeb… - BMC chemistry, 2024 - Springer
A receptor-based pharmacophore model describing the binding features required for the
multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were …
multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were …
Design, synthesis, molecular docking studies and in silico prediction of ADME properties of new 5-nitrobenzimidazole/thiopyrimidine hybrids as anti-angiogenic …
H Abdelmohsen, AM El Kerdawy - Egyptian Journal of Chemistry, 2024 - journals.ekb.eg
In the current study, a new series of 5-nitrobenzimidazole-pyrimidine hybrids 12a, b, 13 and
14a-c were designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. The …
14a-c were designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. The …
Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers
SS Zahran, FA Ragab, AM Soliman, MG El-Gazzar… - Bioorganic …, 2024 - Elsevier
In a search for new anticancer agents with better activity and selectivity, the present work
described the synthesis of several new series of sulfachloropyridazine hybrids with …
described the synthesis of several new series of sulfachloropyridazine hybrids with …
Quinazoline‐oxindole hybrids as angiokinase inhibitors and anticancer agents: Design, synthesis, biological evaluation, and molecular docking studies
YM Syam, SS Abd El‐Karim… - Archiv der …, 2024 - Wiley Online Library
Two new sets of quinazoline‐oxindole 8a–l and quinazoline‐dioxoisoindoline 10a–d
hybrids were designed as type II angiokinase inhibitors and anticancer agents. The design …
hybrids were designed as type II angiokinase inhibitors and anticancer agents. The design …
Pd-Catalysed Regioselective Cross Dehydrogenative Coupling of Quinazolinones with Aromatic Carboxylic Acids
D Waghmare, PM Lagad, U Kshirsagar… - Available at SSRN … - papers.ssrn.com
A simple protocol for a regioselective cross dehydrogenative reaction of 2-aryl-
quinazolinones with different phenyl carboxylic acids was developed using palladium …
quinazolinones with different phenyl carboxylic acids was developed using palladium …