Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

The secretory capacity of a cell is constantly challenged by physiological demands and
pathological perturbations. To adjust and match the protein-folding capacity of the …

Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Reactive oxygen species (ROS) are short-lived and highly reactive molecules. The
generation of ROS in cells exists in equilibrium with a variety of antioxidant defences. At low …

To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

Progress has been made in our understanding of the mechanisms of endoplasmic reticulum
(ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress …

The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …

Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is
observed in many physiological and pathological conditions. To cope with endoplasmic …