Auger electrons for cancer therapy–a review
Abstract Background Auger electrons (AEs) are very low energy electrons that are emitted
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …
[HTML][HTML] Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research
A Ivashkevich, CE Redon, AJ Nakamura, RF Martin… - Cancer letters, 2012 - Elsevier
Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases
The blood-brain barrier (BBB) is an important factor limiting the effectiveness of central
nervous system (CNS) therapeutics. MR-guided focused ultrasound (MRgFUS) is a …
nervous system (CNS) therapeutics. MR-guided focused ultrasound (MRgFUS) is a …
HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and …
B Altunay, A Morgenroth, M Beheshti, A Vogg… - European journal of …, 2021 - Springer
Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …
The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles
The current study describes the impact of particle size and/or molecular targeting (epidermal
growth factor, EGF) on the in vivo transport of block copolymer micelles (BCMs) in athymic …
growth factor, EGF) on the in vivo transport of block copolymer micelles (BCMs) in athymic …
Therapeutic radionuclides: biophysical and radiobiologic principles
AI Kassis - Seminars in nuclear medicine, 2008 - Elsevier
Although the general radiobiologic principles underlying external beam therapy and
radionuclide therapy are the same, there are significant differences in the biophysical and …
radionuclide therapy are the same, there are significant differences in the biophysical and …
Nuclear Targeting Dynamics of Gold Nanoclusters for Enhanced Therapy of HER2+ Breast Cancer
Recent advances in fluorescent metal nanoclusters have spurred tremendous interest in
nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more …
nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more …
Targeted radionuclide therapy in combined-modality regimens
Targeted radionuclide therapy (TRT) is a branch of cancer medicine concerned with the use
of radioisotopes, radiolabelled molecules, nanoparticles, or microparticles that either …
of radioisotopes, radiolabelled molecules, nanoparticles, or microparticles that either …
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons
Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …