Oxidative stress and cellular pathologies in Parkinson's disease
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
Neurodegenerative and neurological disorders by small inhaled particles
HJ Heusinkveld, T Wahle, A Campbell, RHS Westerink… - Neurotoxicology, 2016 - Elsevier
The world⿿ s population is steadily ageing and as a result, health conditions related to
ageing, such as dementia, have become a major public health concern. In 2001, it was …
ageing, such as dementia, have become a major public health concern. In 2001, it was …
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Abstract α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …
Neuropathology of incidental Lewy body & prodromal Parkinson's disease
T Koeglsperger, SL Rumpf, P Schließer… - Molecular …, 2023 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
Mechanisms of dopamine transporter regulation in normal and disease states
RA Vaughan, JD Foster - Trends in pharmacological sciences, 2013 - cell.com
The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
The hallmarks of P arkinson's disease
Since the discovery of dopamine as a neurotransmitter in the 1950s, P arkinson's disease
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …
Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation
Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the
substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A …
substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A …
Parkinson's disease: from synaptic loss to connectome dysfunction
A Bellucci, NB Mercuri, A Venneri… - Neuropathology and …, 2016 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …
The air we breathe: air pollution as a prevalent proinflammatory stimulus contributing to neurodegeneration
M Jankowska-Kieltyka, A Roman… - Frontiers in Cellular …, 2021 - frontiersin.org
Air pollution is regarded as an important risk factor for many diseases that affect a large
proportion of the human population. To date, accumulating reports have noted that …
proportion of the human population. To date, accumulating reports have noted that …
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
Abstract α-Synuclein becomes misfolded and aggregated upon damage by various factors,
for example, by reactive oxygen species. These aggregated forms have been proposed to …
for example, by reactive oxygen species. These aggregated forms have been proposed to …