The successful assembly of large supramolecular structures infers a delicate balance
between reversible noncovalent interactions which are capable of undergoing correction …

Amphipols (APols) are short amphipathic polymers that can substitute for detergents at the
transmembrane surface of membrane proteins (MPs) and, thereby, keep them soluble in …

Over the past decade, the structural biology of membrane proteins (MPs) has taken a new
turn thanks to epoch-making technical progress in single-particle electron cryo-microscopy …

Membrane proteins are traditionally extracted and purified in detergent for biochemical and
structural characterisation. This process is often costly and laborious, and the stripping away …

One of the biggest challenges in membrane protein (MP) research is to secure
physiologically relevant structural and functional information after extracting MPs from their …

Membrane proteins are essential for cellular growth, signalling and homeostasis, making up
a large proportion of therapeutic targets. However, the necessity for a solubilising agent to …

Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane
proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have …

Recent developments in native mass spectrometry and ion mobility have made it possible to
analyze the composition and structure of membrane protein complexes in the gas-phase. In …

A new vaccine formulated with the Chlamydia muridarum native major outer membrane
protein (nMOMP) and amphipols was assessed in an intranasal (in) challenge mouse …

Amphipols (APols) are short amphipathic polymers developed as an alternative to
detergents for handling membrane proteins (MPs) in aqueous solution. MPs are, as a rule …