The overproduction of reactive oxygen species (ROS) generates oxidative stress in cells.
Oxidative stress results in various pathophysiological conditions, especially cancers and …

A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis
in the brain is critical for the prevention of accumulating oxidative damage. Aging is the …

Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of PD. It is known that …

Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the
indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …

Nuclear factor E2–related factor 2 (Nrf2) is a transcription factor known to induce expression
of a variety of cytoprotective and detoxification genes. Several of the genes commonly …

Oxidative and nitrosative stress underlie the pathogenesis of a broad range of human
diseases, in particular neurodegenerative disorders. Within the brain, neurons are the cells …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates
hundreds of antioxidant genes, and is activated in response to oxidative stress. Given that …

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by cell
loss in the substantia nigra resulting in striatal dopamine depletion. Although the cause of …