Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …

In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

Cochlear implantation has become the most effective treatment method for patients with
profound and total hearing loss. However, its therapeutic efficacy is dependent on the …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Abstract Models of the human auditory periphery range from very basic functional
descriptions of auditory filtering to detailed computational models of cochlear mechanics …

Our sense of hearing enables the processing of stimuli that differ in sound pressure by more
than six orders of magnitude. How to process a wide range of stimulus intensities with …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

Understanding the biology of the previously underappreciated sensitivity of cochlear
synapses to noise insult, and its clinical consequences, is becoming a mission for a growing …