Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Preeclampsia is a progressive, multisystem pregnancy disorder. According to the time of
onset or delivery, preeclampsia has been subclassified into early-onset (< 34 weeks) and …

Objectives The heterogeneous nature of preeclampsia is a major obstacle to early screening
and prevention, and a molecular taxonomy of disease is needed. We have previously …

BACKGROUND Preeclampsia screening is a critical component of antenatal care
worldwide. Currently, the most developed screening test for preeclampsia at 11 to 13 weeks' …

Proteoglycan macromolecules play key roles in several physiological processes (eg,
adhesion, proliferation, migration, invasion, angiogenesis, and apoptosis), all of which are …

Introduction Galectins are master regulators of maternal immune responses and
placentation in pregnancy. Galectin-13 (gal-13) and galectin-14 (gal-14) are expressed …

Background Placental dysfunction, a root cause of common syndromes affecting human
pregnancy, such as preeclampsia (PE), fetal growth restriction (FGR), and spontaneous …

Background Preeclampsia, especially preterm preeclampsia and early-onset preeclampsia,
is a life-threating pregnancy disorder, and the heterogeneity and complexity of preeclampsia …

8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of
the free radical-induced oxidative damage product of DNA, which may allow a premature …

Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (eg
preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The …