Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Caloric restriction, fasting, and exercise have long been recognized for their neuroprotective
and lifespan-extending properties; however, the underlying mechanisms of these …

Sirt3, as a major mitochondrial nicotinamide adenine dinucleotide (NAD)-dependent
deacetylase, is required for mitochondrial metabolic adaption to various stresses. However …

Metabolites, including those generated during ethanol metabolism, can impact disease
states by binding to transcription factors and/or modifying chromatin structure, thereby …

NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …

Sirtuins are NAD+-dependent protein deacetylases and have been implicated in the
regulation of metabolism, stress responses, and aging. Three sirtuins are located in …

Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying
mechanisms are poorly understood. Age-related damage to mitochondria may be a critical …