American Association of Clinical Endocrinology clinical practice guideline for the diagnosis and management of nonalcoholic fatty liver disease in primary care and …

K Cusi, S Isaacs, D Barb, R Basu, S Caprio… - Endocrine Practice, 2022 - Elsevier
Objective To provide evidence-based recommendations regarding the diagnosis and
management of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis …

Challenges and opportunities in NASH drug development

SA Harrison, AM Allen, J Dubourg, M Noureddin… - Nature medicine, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis–2021 update

CPG Panel, A Berzigotti, E Tsochatzis, J Boursier… - Journal of …, 2021 - Elsevier
Non-invasive tests are increasingly being used to improve the diagnosis and
prognostication of chronic liver diseases across aetiologies. Herein, we provide the latest …

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

D Ferguson, BN Finck - Nature Reviews Endocrinology, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

FE Mózes, JA Lee, EA Selvaraj, ANA Jayaswal… - Gut, 2022 - gut.bmj.com
Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic
fatty liver disease. The aims of this study were to evaluate the individual diagnostic …

Current therapies and new developments in NASH

JF Dufour, QM Anstee, E Bugianesi, S Harrison… - Gut, 2022 - gut.bmj.com
Non-alcoholic steatohepatitis is becoming the most important aetiology for advanced liver
disease. There has been important progress in the field in recent years and the complexity of …

Impact of non-invasive biomarkers on hepatology practice: past, present and future

QM Anstee, L Castera, R Loomba - Journal of hepatology, 2022 - Elsevier
Over the last two decades, there have been tremendous advances in the non-invasive
diagnosis and risk stratification of chronic liver diseases (CLDs). Non-invasive approaches …

Therapeutic pipeline in nonalcoholic steatohepatitis

R Vuppalanchi, M Noureddin, N Alkhouri… - Nature reviews …, 2021 - nature.com
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …

Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD

N Tamaki, V Ajmera, R Loomba - Nature Reviews Endocrinology, 2022 - nature.com
Hepatic steatosis is a key histological feature of nonalcoholic fatty liver disease (NAFLD).
The non-invasive quantification of liver fat is now possible due to advances in imaging …

Advanced liver fibrosis is common in patients with type 2 diabetes followed in the outpatient setting: the need for systematic screening

R Lomonaco, E Godinez Leiva, F Bril… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver
fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 …