Human diseases such as cancer can be caused by aberrant epigenetic regulation.
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …

Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy
modes employed, including chemotherapy and radiotherapy, have been reported to be …

Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are
universally able to bind NAD+, and activate it to effect ADP-ribosylation of cellular …

The bone protective effects of resveratrol have been demonstrated in several osteoporosis
models while the underlying mechanism is largely unclear. In the present study, we …

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its
potential therapeutic use in the treatment of many diseases, including cancer, diabetes …

Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member
of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no …

SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms.
Its role in mammals is incompletely understood, but includes modulation of at least 34 …

Background RNA adenosine modifications, which are primarily mediated by “writer”
enzymes (RMWs), play a key role in epigenetic regulation in various biological processes …

Osteosarcomas, the most common malignant bone tumors, show a potent capacity for local
invasion and pulmonary metastasis. Resveratrol (RESV), a phytochemical, exhibits multiple …

The skeleton is a multifunctional and regenerative organ. Dynamic activities within the bone
microenvironment necessitate and instigate rapid and temporal changes in gene expression …