Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …

Spinal cord injury disrupts the communication between the brain and the spinal circuits that
orchestrate movement. To bypass the lesion, brain–computer interfaces,, have directly …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits
producing leg movement. Failure of these projections to reorganize leads to permanent …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

Study Design: PRISMA-guided systematic review. Objectives: To provide a comprehensive
framework of the current animal models for investigating spinal cord injury (SCI) and …

Epidural electrical stimulation of lumbar segments facilitates standing and walking in animal
models and humans with spinal cord injury. However, the mechanisms through which this …