[HTML][HTML] Nanotechnology for topical drug delivery to the anterior segment of the eye

A Vaneev, V Tikhomirova, N Chesnokova… - International journal of …, 2021 - mdpi.com
Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are
the most prevalent drug form, especially for widely distributed anterior segment eye …

[HTML][HTML] Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

[HTML][HTML] Development of lactoferrin-loaded liposomes for the management of dry eye disease and ocular inflammation

A López-Machado, N Díaz-Garrido, A Cano, M Espina… - Pharmaceutics, 2021 - mdpi.com
Dry eye disease (DED) is a high prevalent multifactorial disease characterized by a lack of
homeostasis of the tear film which causes ocular surface inflammation, soreness, and visual …

[HTML][HTML] Nutraceuticals: a promising therapeutic approach in ophthalmology

CR Castro-Castaneda, F Altamirano-Lamarque… - Nutrients, 2022 - mdpi.com
Oxidative stress represents one of the main factors driving the pathophysiology of multiple
ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma …

Trends in formulation approaches for sustained drug delivery to the posterior segment of the eye

A Biswas, AD Choudhury, AC Bisen, S Agrawal… - AAPS …, 2023 - Springer
The eye, an intricate organ comprising physical and physiological barriers, poses a
significant challenge for ophthalmic physicians seeking to treat serious ocular diseases …

Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment

H Jiang, Z Xu - Drug Delivery, 2023 - Taylor & Francis
Ocular posterior segment diseases such as uveitis, X-linked juvenile retinoschisis, or age-
related macular degeneration usually result in progressive and irreversible vision loss …

Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives

KK Abla, MM Mehanna - Journal of Controlled Release, 2023 - Elsevier
Eye is the most specialized and sensory body organ and treating eye diseases efficiently is
necessary. Despite various attempts, the design of a consummate ophthalmic drug delivery …

[HTML][HTML] Cannabidiol nanoemulsion for eye treatment–Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute

O Strnad, J Šuman, T Veverková, A Sukupová… - International Journal of …, 2023 - Elsevier
Cannabidiol (CBD) is the non-psychoactive component of the plant Cannabis sativa (L.) that
has great anti-inflammatory benefits and wound healing effects. However, its high …

The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure

L Rebibo, M Frušić-Zlotkin, R Ofri, T Nassar… - International Journal of …, 2022 - Elsevier
Cannabidiol (CBD) is a phytocannabinoid that has a great clinical therapeutic potential. Few
studies have been published on its efficacy in ocular inflammations while its impact on …

Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment

KM Hosny, WY Rizg, HM Alkhalidi, WA Abualsunun… - Drug Delivery, 2021 - Taylor & Francis
Natamycin (NT) is a synthetic broad-spectrum antifungal used in eye drops. However, it has
low solubility and high molecular weight, limiting its permeation, and generally causes eye …