Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually
seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …

Most heritable diseases are polygenic. To comprehend the underlying genetic architecture,
it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic …

The autonomic nervous system regulates pancreatic function. Islet capillaries are essential
for the extension of axonal projections into islets, and both of these structures are important …

Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves
blood glucose regulation by replenishing the endogenous beta cells destroyed by …

Insulin is an essential regulator of blood glucose homeostasis that is produced exclusively
by β cells within the pancreatic islets of healthy individuals. In those affected by diabetes …

It has become increasingly clear that assessing various parameters of the pancreas is
important in T1D research for a wide variety of reasons. Immune cells in circulating blood …

Richardson et al. – 0 Human pancreatic capillaries and nerve fibers persist in type 1 diabetes
despite beta cell loss Running Page 1 Richardson et al. – 0 Human pancreatic capillaries and …