SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Colorectal cancer (CRC) is a common malignant tumor characterized by unchecked division
and survival of abnormal cells in the colon or rectum with high morbidity and mortality …

Colorectal cancer stem cells (CCSCs) play important roles in the prognosis,
chemoresistance, and treatment failure of colorectal cancer (CRC). Ferroptosis is an …

As a key copper homeostasis-related molecule, lipoyltransferase 1 (LIPT1) is an essential
enzyme for the activation of mitochondrial 2-ketoacid dehydrogenase, participating in fatty …

Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently
attracted significant attention for their role in tumorigenesis and tumour management …

Simple Summary The role of miR-148a-3p in colorectal cancer (CRC) is still debated. In this
study, the in vitro antineoplastic effect of miR-148a-3p overexpression in the CRC model is …

Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors.
However, single treatment modalities are often restricted due to biochemical recurrence and …

Aberrant metabolism has been identified as a main driver of cancer. Profiling of metabolism-
related pathways in cancer furthers the understanding of tumor plasticity and identification of …

Background The effectiveness of conservative treatment of endometrial carcinoma (EC) with
oral progesterone therapy, such as medroxyprogesterone acetate (MPA), can be blunted …

Background: Overexpression of solute carrier family 7 member 8 (SLC7A8) has been shown
to relate to the survival time and tumor progression in cancer patients. However, the role of …