COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

J Loo, DA Spittle, M Newnham - Thorax, 2021 - thorax.bmj.com
Thrombotic events that frequently occur in COVID-19 are predominantly venous
thromboemboli (VTE) and are associated with increasing disease severity and worse clinical …

Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and …

BM Henry, J Vikse, S Benoit, EJ Favaloro, G Lippi - Clinica chimica acta, 2020 - Elsevier
Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19),
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are …

[HTML][HTML] Neutrophil extracellular traps in COVID-19

Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo… - JCI insight, 2020 - ncbi.nlm.nih.gov
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin …

COVID–19-associated coagulopathy: An exploration of mechanisms

ME Colling, Y Kanthi - Vascular Medicine, 2020 - journals.sagepub.com
An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to
the virus SARS-CoV-2, has infected millions of people and remains a threat to many more …

[HTML][HTML] Neutrophil extracellular traps and thrombosis in COVID-19

Y Zuo, M Zuo, S Yalavarthi, K Gockman… - Journal of Thrombosis …, 2021 - Springer
Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation
and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood …

[HTML][HTML] Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research

B Bikdeli, MV Madhavan, A Gupta… - Thrombosis and …, 2020 - thieme-connect.com
Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The …

[HTML][HTML] Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public …

[HTML][HTML] The role of neutrophil extracellular traps in acute lung injury

D Scozzi, F Liao, AS Krupnick, D Kreisel… - Frontiers in …, 2022 - frontiersin.org
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

[HTML][HTML] Endothelial damage in acute respiratory distress syndrome

AG Vassiliou, A Kotanidou, I Dimopoulou… - International journal of …, 2020 - mdpi.com
The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …