The secret ally: immunostimulation by anticancer drugs
It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …
system, has a crucial role in modulating tumour progression and response to therapy …
Teriflunomide and its mechanism of action in multiple sclerosis
Abstract Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments
(DMTs) must both limit unwanted immune responses associated with disease initiation and …
(DMTs) must both limit unwanted immune responses associated with disease initiation and …
[HTML][HTML] Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity
Immune-based interventions are promising strategies to achieve long-term cancer-free
survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy …
survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy …
Immunological aspects of cancer chemotherapy
L Zitvogel, L Apetoh, F Ghiringhelli… - Nature reviews …, 2008 - nature.com
Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …
crucial contribution to the antitumour effects of conventional chemotherapy-based and …
[HTML][HTML] Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?
Recent clinical trials revealed the impressive efficacy of immunological checkpoint blockade
in different types of metastatic cancers. Such data underscore that immunotherapy is one of …
in different types of metastatic cancers. Such data underscore that immunotherapy is one of …
The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)
DJ Mahad, RM Ransohoff - Seminars in immunology, 2003 - Elsevier
Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human
central nervous system (CNS). In MS, CNS inflammation is associated with demyelination …
central nervous system (CNS). In MS, CNS inflammation is associated with demyelination …
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
PA Muraro, DC Douek, A Packer, K Chung… - The Journal of …, 2005 - rupress.org
Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT)
can persistently suppress inflammatory disease activity in a subset of patients with severe …
can persistently suppress inflammatory disease activity in a subset of patients with severe …
Diagnosis and management of multiple sclerosis
PA Calabresi - American family physician, 2004 - aafp.org
Multiple sclerosis, an idiopathic inflammatory disease of the central nervous system, is
characterized pathologically by demyelination and subsequent axonal degeneration. The …
characterized pathologically by demyelination and subsequent axonal degeneration. The …
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
HL Weiner - Annals of Neurology: Official Journal of the …, 2009 - Wiley Online Library
Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …
Multiple sclerosis is an inflammatory T-cell–mediated autoimmune disease
HL Weiner - Archives of neurology, 2004 - jamanetwork.com
The etiology and pathogenesis of multiple sclerosis (MS) have been much debated during
the past 50 years. It is now recognized that MS is a complex disease with different clinical …
the past 50 years. It is now recognized that MS is a complex disease with different clinical …