The secret ally: immunostimulation by anticancer drugs

L Galluzzi, L Senovilla, L Zitvogel… - Nature reviews Drug …, 2012 - nature.com
It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …

Teriflunomide and its mechanism of action in multiple sclerosis

A Bar-Or, A Pachner, F Menguy-Vacheron, J Kaplan… - Drugs, 2014 - Springer
Abstract Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments
(DMTs) must both limit unwanted immune responses associated with disease initiation and …

[HTML][HTML] Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity

S Di Biase, C Lee, S Brandhorst, B Manes, R Buono… - Cancer cell, 2016 - cell.com
Immune-based interventions are promising strategies to achieve long-term cancer-free
survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy …

Immunological aspects of cancer chemotherapy

L Zitvogel, L Apetoh, F Ghiringhelli… - Nature reviews …, 2008 - nature.com
Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

[HTML][HTML] Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?

L Apetoh, S Ladoire, G Coukos, F Ghiringhelli - Annals of Oncology, 2015 - Elsevier
Recent clinical trials revealed the impressive efficacy of immunological checkpoint blockade
in different types of metastatic cancers. Such data underscore that immunotherapy is one of …

The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)

DJ Mahad, RM Ransohoff - Seminars in immunology, 2003 - Elsevier
Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human
central nervous system (CNS). In MS, CNS inflammation is associated with demyelination …

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients

PA Muraro, DC Douek, A Packer, K Chung… - The Journal of …, 2005 - rupress.org
Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT)
can persistently suppress inflammatory disease activity in a subset of patients with severe …

Diagnosis and management of multiple sclerosis

PA Calabresi - American family physician, 2004 - aafp.org
Multiple sclerosis, an idiopathic inflammatory disease of the central nervous system, is
characterized pathologically by demyelination and subsequent axonal degeneration. The …

The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?

HL Weiner - Annals of Neurology: Official Journal of the …, 2009 - Wiley Online Library
Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …

Multiple sclerosis is an inflammatory T-cell–mediated autoimmune disease

HL Weiner - Archives of neurology, 2004 - jamanetwork.com
The etiology and pathogenesis of multiple sclerosis (MS) have been much debated during
the past 50 years. It is now recognized that MS is a complex disease with different clinical …