Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis

S Liu, Z Wang, Y Su, L Qi, W Yang, M Fu, X Jing… - Nature, 2021 - nature.com
Somatosensory autonomic reflexes allow electroacupuncture stimulation (ES) to modulate
body physiology at distant sites,,,,–(for example, suppressing severe systemic inflammation …

Sepsis-induced immunosuppression

LK Torres, P Pickkers… - Annual review of …, 2022 - annualreviews.org
Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

M Merad, JC Martin - Nature reviews immunology, 2020 - nature.com
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than
200,000 deaths worldwide. Several studies have now established that the …

Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study

D Liao, F Zhou, L Luo, M Xu, H Wang, J Xia… - The Lancet …, 2020 - thelancet.com
Background COVID-19 is an ongoing global pandemic. Changes in haematological
characteristics in patients with COVID-19 are emerging as important features of the disease …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

PS Arunachalam, F Wimmers, CKP Mok, RAPM Perera… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …

Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare

KH Goh, L Wang, AYK Yeow, H Poh, K Li… - Nature …, 2021 - nature.com
Sepsis is a leading cause of death in hospitals. Early prediction and diagnosis of sepsis,
which is critical in reducing mortality, is challenging as many of its signs and symptoms are …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …