B cells play a central role in the pathogenesis in multiple sclerosis (MS), being involved in
the activation of proinflammatory T cells, secretion of proinflammatory cytokines, and …

An increase in autoimmune diseases poses a socioeconomic challenge worldwide.
Predisposing genetic risk has been identified, yet environmental factors make up a …

The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …

The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

There is a strong unmet clinical need for objective body fluid biomarkers to assist early
diagnosis and estimate long-term prognosis, monitor treatment response and predict …

Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative
disease of the central nervous system (CNS). It is characterized by demyelination and …

This review, focused on demyelination in multiple sclerosis, is divided in two parts. The first
part addresses the many and not exclusive mechanisms leading to demyelination in the …

Immunotherapy is the field of immunology that aims to identify treatments for diseases
through induction, enhancement or suppression of an immune response. Immunotherapies …

Background Clinicians caring for patients with Multiple Sclerosis (MS) need improved
biomarkers to aid them in disease management. Objective We assessed the predictive value …

Gray matter lesions are thought to play a key role in the progression of disability and
cognitive impairment in multiple sclerosis (MS) patients, but whether gray matter damage is …