Alemtuzumab (previously known as Campath®) is a humanized monoclonal antibody
directed against the CD52 antigen on mature lymphocytes that results in lymphopenia and …

Recent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently,
several molecules participating in B cell survival and proliferation, including B-cell activating …

Pathogenic CD4+ T cells and myeloid cells play critical roles in the pathogenesis of multiple
sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of …

Objective Cladribine tablet therapy is an efficacious treatment for multiple sclerosis (MS),
however, its mechanism of action on T and B cell subsets remains unclear. The purpose of …

In recent years, in the effort to find a potential innovative therapy for multiple sclerosis (MS),
researchers focused on transplantation of mesenchymal stem cells (MSCs) due to their well …

We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple
sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and …

Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous
system (CNS) for which several new treatment options were recently introduced. Among …

Background There is evidence that B cells play an important role in disease pathology of
multiple sclerosis (MS). The aim of this prospective observational study was to determine the …

Glucocorticoids (GCs) are the most commonly prescribed drugs for the treatment of acute
disease bouts in multiple sclerosis (MS) patients. While T lymphocytes were shown to be …

Neuroaxonal injury and loss result in the release of cytoskeleton components, including
neurofilaments, into the cerebrospinal fluid and peripheral blood. Once released …