Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via
the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

KRAS mutation, which occurs in∼ 95% of pancreatic ductal adenocarcinoma (PDA), has
been shown to program tumor metabolism. MCT4 is highly upregulated in a subset of PDA …

Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and
their interaction with cancer cells facilitates cancer progression. This study investigated the …

MicroRNAs are short noncoding RNAs consisting of 18–25 nucleotides that target specific
mRNA moieties for translational repression or degradation, thereby modulating numerous …

Molecular and cellular mechanisms underlying resistance/low responsiveness to
antiangiogenic compounds are under extensive investigations. Both populations of tumor …

The MET pathway is dysregulated in many human cancers and promotes tumour growth,
invasion and dissemination. Abnormalities in MET signalling have been reported to …

Immune checkpoint inhibitor therapy has revolutionized the field of cancer immunotherapy.
Even though it has shown a durable response in some solid tumors, several patients do not …

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic
extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over …

The hepatocyte growth factor (HGF) and its receptor, c-Met, have been implicated in driving
proliferation, invasion, and poor prognosis in pancreatic cancer. Here, we investigated the …