摘要全球科学家在新冠病毒疫情的巨大挑战中从未停止免疫学研究的步伐, 2022
年免疫学仍然取得了长足进展. 概述了2022 年免疫学研究的热点及进展, 包括T 细胞记忆 …

The biological function of the male hormones (androgens) is orchestrated through the
activation of the androgen receptor-mediated signaling events that are central to the …

Immune-based therapies induce durable remissions in subsets of patients across multiple
malignancies. However, there is limited efficacy of immunotherapy in metastatic castrate …

Background The introduction of tyrosine kinase inhibitors (TKI) has greatly improved the
management of metastatic melanoma. Recent studies have uncovered a relationship …

Metastatic skin cutaneous melanomas remain a significant clinical problem. In particular,
those melanomas that do not contain a gain-of-function BRAF allele remain challenging to …

Targeted therapies against mutant BRAF are effectively used in combination with MEK
inhibitors (MEKi) to treat advanced melanoma. However, treatment success is affected by …

Заболеваемость злокачественными новообразованиями нерепродуктивных органов,
как карциномами, так и саркомами, и смертность от них у мужчин в 1, 5 раза выше, чем …

Zusammenfassung Hintergrund Die Einführung von Tyrosinkinaseinhibitoren (TKI) hat die
Behandlung von Patienten mit metastasiertem Melanom erheblich verbessert. Aktuelle …

Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells
and are associated with durable immune responses. However, lymph nodes are often the …

Although tremendous progress has been made in understanding the mechanisms leading to
cancer, those governing metastases are still poorly understood. E-cadherin (Ecad) is a cell …