Acid-base regulation by the kidneys is largely missing in end-stage renal disease patients
undergoing hemodialysis (HD). Bicarbonate is added to the dialysis fluid during HD to …

Introduction Abnormalities in blood bicarbonates (HCO3–) concentration are a common
finding in patients with chronic kidney disease, especially at the end-stage renal failure …

In this study, we present a new protocol for kidney replacement therapy (hemodialysis),
based on an explicitly solvable mathematical model. With current protocols, the high and …

The acid-base goal of intermittent hemodialysis is to replenish buffers consumed by
endogenous acid production and expansion acidosis in the period between treatments. The …

Background: The hydrogen ion (H+) mobilisation model has been previously shown to
accurately describe blood bicarbonate (HCO3) kinetics during haemodialysis (HD) when the …

TO THE EDITOR: Several years ago, we addressed the question of why blood bicarbonate
concentration ([HCO3 À]) fails to increase notably during the last half of a standard …

1) We performed detailed measurements of blood from both the arterial and venous limbs of
the hemodialysis circuit and of dialysate. Results of these analyses, for both bicarbonate …