[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer
NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …
Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation
T Yamazaki, S Souquere, T Chujo, S Kobelke… - Molecular cell, 2018 - cell.com
A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body
construction; however, specific RNA domains dictating their architectural functions remain …
construction; however, specific RNA domains dictating their architectural functions remain …
[HTML][HTML] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using
comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) …
comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) …
Remodeling oncogenic transcriptomes by small molecules targeting NONO
SG Kathman, SJ Koo, GL Lindsey, HL Her… - Nature chemical …, 2023 - nature.com
Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly …
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly …
K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis
XL Zhang, XH Chen, B Xu, M Chen, S Zhu… - Nature …, 2023 - nature.com
Abstract N6-methyladenosine (m6A) modification plays important roles in bioprocesses and
diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases. Here, we reveal that …
diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases. Here, we reveal that …
[HTML][HTML] NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation
Detection of viruses by innate immune sensors induces protective antiviral immunity. The
viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for detection of HIV by …
viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for detection of HIV by …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis
Activation of metastatic reprogramming is critical for tumour metastasis. However, more
detailed knowledge of the underlying mechanism is needed to enable targeted intervention …
detailed knowledge of the underlying mechanism is needed to enable targeted intervention …
Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria
The long noncoding RNA NEAT1 (nuclear enriched abundant transcript 1) nucleates the
formation of paraspeckles, which constitute a type of nuclear body with multiple roles in …
formation of paraspeckles, which constitute a type of nuclear body with multiple roles in …