SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …

Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

[HTML][HTML] Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

S Weingarten-Gabbay, S Klaeger, S Sarkizova… - Cell, 2021 - cell.com
T cell-mediated immunity plays an important role in controlling SARS-CoV-2 infection, but
the repertoire of naturally processed and presented viral epitopes on class I human …

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

I Jungreis, R Sealfon, M Kellis - Nature communications, 2021 - nature.com
Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

A SARS-CoV-2–host proximity interactome

P Samavarchi-Tehrani, H Abdouni, JDR Knight… - BioRxiv, 2020 - biorxiv.org
Viral replication is dependent on interactions between viral polypeptides and host proteins.
Identifying virus-host protein interactions can thus uncover unique opportunities for …

[HTML][HTML] Covid-19: virology, variants, and vaccines

M Young, H Crook, J Scott, P Edison - BMJ medicine, 2022 - ncbi.nlm.nih.gov
Abstract As of 25 January 2022, over 349 million individuals have received a confirmed
diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS …

The functional importance of VCP to maintaining cellular protein homeostasis

BA Ahlstedt, R Ganji, M Raman - Biochemical Society …, 2022 - portlandpress.com
The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing
protein (VCP), is essential for many cellular pathways including but not limited to …