Development of 111 In labeled insulin for receptor imaging/therapy

A Jalilian, J Garousi, M Akhlaghi… - … of radioanalytical and …, 2009 - akjournals.com
In order to target insulin receptors in various diabetic and insulinoma conditions, human
recombinant insulin was successively labeled with [111 In]-indium chloride after conjugation …

Anticancer activity of organogallium (III) complexes in colon cancer cells

R KaluĦ, S Gómez-Ruiz - Anti-Cancer Agents in Medicinal …, 2016 - ingentaconnect.com
In vitro antitumor activity of various organogallium (III) complexes (1–8) has been tested
against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used …

Coordination-Mediated Synthesis of 67Ga-Labeled Purification-Free Trivalent Probes for in Vivo Imaging of Saturable Systems

HA Holik, T Uehara, S Nemoto, T Rokugawa… - Bioconjugate …, 2018 - ACS Publications
A large excess of unlabeled ligands over gallium-67 (67Ga) provides 67Ga-labeled probes
with high radiochemical yields in a short reaction time. However, the unlabeled ligands …

Stabilities of gallium (III), iron (III), and indium (III) chelates of hydroxyaromatic ligands with different overall charges

R Motekaitis, Y Sun, AE Martell, MJ Welch - Inorganic Chemistry, 1991 - ACS Publications
The stability constants of the Ga (III), In (III), and Fe (III) chelates of three new ligands, A'-(2-
hydroxybenzyl)-A"-(pyridoxyl)-ethylenediamine-/V,/V'-diacetic acid (HBPLED), 7V-(2 …

Cyclotron production of 67Ga (III) with a tandem natGe− natZn target

C Naidoo, TN Van der Walt - Applied Radiation and Isotopes, 2001 - Elsevier
Production of 67Ga (III) at the National Accelerator Centre is by proton bombardment of a
natZn target, and uses 15− 20h of cyclotron beam time per production. A study was …

Design considerations towards simultaneously radiolabeled and fluorescent imaging probes incorporating metallic species

SI Pascu, PA Waghorn, T Conry, B Lin, C James… - Advances in Inorganic …, 2009 - Elsevier
Publisher Summary This chapter discusses some of the recent developments in molecular
imaging with a view to describe the overall design considerations for probes that may be …

Radiopharmaceuticals based on polyaminophosphonic acids labeled with α−, β−, and γ-emitting radionuclides

VK Tishchenko, VM Petriev, VG Skvortsov - Pharmaceutical Chemistry …, 2015 - Springer
This review presents results on the pharmacokinetic characteristics of osteotropic
radiopharmaceuticals (RP) based on polyaminophosphonic acids labeled with various …

Concentration of 68Ga via solvent extraction

TH Bokhari, A Mushtaq, IU Khan - Applied Radiation and Isotopes, 2009 - Elsevier
The metallic cation, 68Ga (III) is suitable for complexation with chelators either naked or
conjugated with biological macromolecules, however, such labeling procedure requires …

Transferrin dependence of Ga(NO3)3 inhibition of growth in human‐derived small cell lung cancer cells

RE Weiner, I Avis, RD Neumann… - Journal of Cellular …, 1996 - Wiley Online Library
The effect of a combination of anti‐transferrin receptor (TFR) antibody, 42/6, and Ga (No3) 3
on cell growth was examined in small cell lung cancer (SCLC) cell lines: classic, NCl‐H209 …

Production of Short Half‐Life PET Radionuclides

MR Kilbourn, ME Rodnick… - Handbook of …, 2020 - Wiley Online Library
This chapter discusses the production methods for the most commonly used short‐lived
positron emission tomography (PET) radionuclides, with an emphasis on the methods used …