In recent years, genome-wide analyses of patients have resulted in the identification of a
number of neurodevelopmental disorders. Several of them are caused by mutations in …

The metabolic microenvironment, comprising all soluble and insoluble nutrients and co-
factors in the extracellular milieu, has a major impact on cancer cell proliferation and …

Dual-specificity phosphatase 8 (DUSP8) is a MAPK phosphatase that dephosphorylates and
inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of …

Resistance to endocrine therapy represents a major concern for patients with estrogen
receptor α–positive (ERα+) breast cancer. Endocrine therapy resistance is commonly …

Metabolic reprogramming is commonly accompanied by alterations in the expression of
metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic …

The RNA-binding protein PURA has been implicated in the rare, monogenetic,
neurodevelopmental disorder PURA Syndrome. PURA binds both DNA and RNA and has …

Objectives PurA is an evolutionary conserved protein that is known to bind to single
stranded DNA or RNA and regulate both transcription and translation. PurA has been …