Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Cardiovascular disease and infections are major causes for the high incidence of morbidity
and mortality of patients with chronic kidney disease. Both complications are directly or …

Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …

The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …

Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …

Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

Abstract Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with
pleiotropic effects that mainly induce protective effects. Our study investigates the …

The current focus on cardiovascular research reflects society's concerns regarding the
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …

Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …