FGF23 and klotho at the intersection of kidney and cardiovascular disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
Immune dysfunction in uremia 2020
G Cohen - Toxins, 2020 - mdpi.com
Cardiovascular disease and infections are major causes for the high incidence of morbidity
and mortality of patients with chronic kidney disease. Both complications are directly or …
and mortality of patients with chronic kidney disease. Both complications are directly or …
Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations
Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …
worldwide. An inverse-graded relationship exists between cardiovascular events and …
Klotho as potential autophagy regulator and therapeutic target
H Zhou, S Pu, H Zhou, Y Guo - Frontiers in Pharmacology, 2021 - frontiersin.org
The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …
Abnormal downregulation of Klotho has been detected in several aging-related diseases …
Klotho in clinical nephrology: diagnostic and therapeutic implications
JA Neyra, MC Hu, OW Moe - … Journal of the American Society of …, 2021 - journals.lww.com
Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …
New potential biomarkers for chronic kidney disease management—A review of the literature
The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …
Inflammation as a precursor of atherothrombosis, diabetes and early vascular aging
E Barbu, MR Popescu, AC Popescu… - International Journal of …, 2022 - mdpi.com
Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …
Soluble klotho as an effective biomarker to characterize inflammatory states
SE Wu, WL Chen - Annals of medicine, 2022 - Taylor & Francis
Abstract Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with
pleiotropic effects that mainly induce protective effects. Our study investigates the …
pleiotropic effects that mainly induce protective effects. Our study investigates the …
The multifunctional contribution of FGF signaling to cardiac development, homeostasis, disease and repair
The current focus on cardiovascular research reflects society's concerns regarding the
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …
The controversy of klotho as a potential biomarker in chronic kidney disease
LX Yu, SS Li, MY Sha, JW Kong, JM Ye… - Frontiers in …, 2022 - frontiersin.org
Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …