[HTML][HTML] Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …
Stargardt disease and progress in therapeutic strategies
Background Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy due to
mutations in ABCA4, characterized by subretinal deposition of lipofuscin-like substances …
mutations in ABCA4, characterized by subretinal deposition of lipofuscin-like substances …
[HTML][HTML] Systematic underestimation of visual sensitivity loss on microperimetry: implications for testing protocols in clinical trials
Purpose: To examine whether systematic changes in visual sensitivity measurements on
microperimetry occur over tests within the same session and whether these changes vary …
microperimetry occur over tests within the same session and whether these changes vary …
[HTML][HTML] Retinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD
M Akula, SM McNamee, Z Love, N Nasraty, NPM Chan… - Gene Therapy, 2024 - nature.com
Degeneration of the macula is associated with several overlapping diseases including age-
related macular degeneration (AMD) and Stargardt Disease (STGD). Mutations in ATP …
related macular degeneration (AMD) and Stargardt Disease (STGD). Mutations in ATP …
Natural history of visual dysfunction in ABCA4 Retinopathy and its genetic correlates
PURPOSE To systematically assess the ability to detect change and retest reliability for a
panel of visual function assessments in ABCA4 retinopathy. DESIGN Prospective natural …
panel of visual function assessments in ABCA4 retinopathy. DESIGN Prospective natural …
[HTML][HTML] Inferred retinal sensitivity in recessive Stargardt disease using machine learning
Spatially-resolved retinal function can be measured by psychophysical testing like fundus-
controlled perimetry (FCP or 'microperimetry'). It may serve as a performance outcome …
controlled perimetry (FCP or 'microperimetry'). It may serve as a performance outcome …
[HTML][HTML] Prediction of function in ABCA4-related retinopathy using ensemble machine learning
Full-field electroretinogram (ERG) and best corrected visual acuity (BCVA) measures have
been shown to have prognostic value for recessive Stargardt disease (also called “ABCA4 …
been shown to have prognostic value for recessive Stargardt disease (also called “ABCA4 …
[HTML][HTML] Visual function and biofeedback training of patients with central vision loss: a review
Y Deng, CH Jie, JW Wang, YY Li… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Older individuals with macular diseases, such as age-related macular degeneration,
experience central vision loss (CVL) due to degeneration of their photoreceptors and retinal …
experience central vision loss (CVL) due to degeneration of their photoreceptors and retinal …
Progression, reliability, predicting parameters and sample size calculations for quantitative fundus autofluorescence measures in ABCA4-related retinopathy
Background/aims To investigate the progression of quantitative autofluorescence (qAF)
measures and the potential as clinical trial endpoint in ABCA4-related retinopathy. Methods …
measures and the potential as clinical trial endpoint in ABCA4-related retinopathy. Methods …