Type 1 diabetes mellitus (T1DM) is the most common autoimmune chronic disease in young
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …

The periodontium is a unique organ from the standpoint of building an organ-on-a-chip
(OoC) since it is a system that is continually threatened by microorganisms, their noxious …

Lack of adequate models significantly hinders advances in prostate cancer treatment, where
resistance to androgen-deprivation therapies and bone metastasis remain as major …

In vitro cellular models denote a crucial part of drug discovery programs as they aid in
identifying successful drug candidates based on their initial efficacy and potency. While …

The immune and endocrine dysfunctions of white adipose tissue are a hallmark of metabolic
disorders such as obesity and type 2 diabetes. In humans, white adipose tissue comprises …

Augmenting adaptive immunity is a critical goal for developing next-generation cancer
therapies. T and B cells infiltrating the tumor dramatically influence cancer progression …

While cartilage tissue engineering has significantly improved the speed and quality of
cartilage regeneration, the underlying metabolic mechanisms are complex, making research …

A comprehensive understanding of the complex physiological and pathological processes
associated with alveolar bones, their responses to different therapeutics strategies, and cell …

Organ-on-a-chip platforms are an emerging technology in experimental and regulatory
toxicology (species-specific differences, ethical considerations). They address gaps …

Epithelial ovarian cancer (EOC) is a heterogeneous disease composed of different cell types
with different molecular aberrations. Traditional cell lines and mice models cannot …