Emerging treatment approaches for triple-negative breast cancer
M Capuozzo, V Celotto, M Santorsola, A Fabozzi… - Medical Oncology, 2023 - Springer
Approximately, 15% of global breast cancer cases are diagnosed as triple-negative breast
cancer (TNBC), identified as the most aggressive subtype due to the simultaneous absence …
cancer (TNBC), identified as the most aggressive subtype due to the simultaneous absence …
Hepatotoxicity of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)
L Zhu, X Yang, S Wu, R Dong, Y Yan, N Lin… - Drug Metabolism …, 2024 - Taylor & Francis
Drug-induced liver injury (DILI) is one of the most frequently adverse reactions in clinical
drug use, usually caused by drugs or herbal compounds. Compared with other populations …
drug use, usually caused by drugs or herbal compounds. Compared with other populations …
DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway
J Zhang, Y Shi, K Ding, W Yu, J He, B Sun - Journal of Experimental & …, 2024 - Springer
Background Hepatocellular carcinoma (HCC) is a fatal malignancy with poor prognosis due
to lack of effective clinical interference. DCAF1 plays a vital role in regulating cell growth and …
to lack of effective clinical interference. DCAF1 plays a vital role in regulating cell growth and …
[HTML][HTML] Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity
B Ge, K Yan, R Sang, W Wang, X Liu, M Yu… - Ecotoxicology and …, 2024 - Elsevier
Due to the rise in temperature and sea level caused by climate change, the detection rate of
aflatoxin B1 (AFB1) in food crops has increased dramatically, and the frequency and severity …
aflatoxin B1 (AFB1) in food crops has increased dramatically, and the frequency and severity …
Targeting EGFR/PI3K/AKT/mTOR signaling in lung and colon cancers: synthesis, antitumor evaluation of new 1, 2, 4-oxdiazoles tethered 1, 2, 3-triazoles
MS Ayoup, I Shawki, H Abdel-Hamid, DA Ghareeb… - RSC …, 2024 - pubs.rsc.org
The EGFR/PI3K/Akt/mTOR pathway is important for metastasis, medication resistance,
apoptosis prevention, and malignant transformation. Mutations in lung and colon cancer …
apoptosis prevention, and malignant transformation. Mutations in lung and colon cancer …
Insights in Molecular Therapies for Hepatocellular Carcinoma
P Heumann, A Albert, K Gülow, D Tümen, M Müller… - Cancers, 2024 - mdpi.com
Simple Summary Molecular directed therapy for hepatocellular carcinoma (HCC) involves
targeting specific signaling pathways that normally promote cancer cell growth and survival …
targeting specific signaling pathways that normally promote cancer cell growth and survival …
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
M Foroutan Kahangi, V Tavakolpour… - Metabolic Brain …, 2024 - Springer
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis.
The cleavage factor Im 25 (CFIm25), a crucial component of the CFIm complex, plays a key …
The cleavage factor Im 25 (CFIm25), a crucial component of the CFIm complex, plays a key …
Cancer‐associated fibroblasts‐secreted exosomal miR‐92a‐3p promotes tumor growth and stemness in hepatocellular carcinoma through activation of Wnt/β‐catenin …
Z Su, C Lu, F Zhang, H Liu, M Li, M Qiao… - Journal of Cellular …, 2024 - Wiley Online Library
Cancer‐associated fibroblasts (CAFs) are a major cellular component in the tumor
microenvironment and have been shown to exhibit protumorigenic effects in hepatocellular …
microenvironment and have been shown to exhibit protumorigenic effects in hepatocellular …
New insights into fibrotic signaling in hepatocellular carcinoma
L Shan, F Wang, W Xue, D Zhai, J Liu, X Lv - Frontiers in Oncology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) mostly occurs in the background of liver fibrosis, and
activated hepatic stellate cells (HSCs) exist in HCC tissues and adjacent tissues. HSC …
activated hepatic stellate cells (HSCs) exist in HCC tissues and adjacent tissues. HSC …
Insights into diosgenin against inflammatory bowel disease as functional food based on network pharmacology and molecular docking
M Cai, Y Mao, W Gao, Z Wang, J Mao, R Sha - Heliyon, 2024 - cell.com
Inflammatory bowel disease (IBD) is a growing global health problem. IBD is commonly
prevalent in Europe and America and the incidence rate in Asia is on the rise due to altered …
prevalent in Europe and America and the incidence rate in Asia is on the rise due to altered …