Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

B cells, plasma cells, and antibodies are commonly found in active central nervous system
(CNS) lesions in patients with multiple sclerosis (MS). B cells isolated from CNS lesions as …

During the last decades, the effort of establishing satisfactory biomarkers for multiple
sclerosis has been proven to be very difficult, due to the clinical and pathophysiological …

In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers
in bodily fluids related to underlying disease mechanisms, disease activity and progression …

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system,
usually occurring in young adults and leading to disability. Despite the progress in …

Background The possibility to better predict the severity of the disease in a patient newly
diagnosed with multiple sclerosis would allow the treatment strategy to be personalized and …

Introduction: Intrathecal B-lymphocyte activation is a hallmark of multiple sclerosis (MS), a
multi-factorial inflammatory-demyelinating disease of the central nervous system. Such …

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous
system, which affects over 2.5 million people worldwide. Although MS has been extensively …

Multiple sclerosis (MS) is the most common neurological disorder leading to permanent
disability in young adults in the developed world. While traditionally conceived as an …