Control of virulence gene expression in S. pyogenes is under the charge of 13 two-
component regulatory systems and at least 30 transcriptional regulators known thus far …

Microbial pathogens balance growth against tissue damage to achieve maximum fitness.
Central carbon metabolism is connected to growth, but how it influences growth/damage …

Streptococcus pyogenes (Group A Streptococcus/GAS or S. pyogenes) is endowed with a
formidable arsenal of virulence factors that allow it to evade host's innate immune responses …

Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and
systemic infections in humans. The molecular mechanisms that contribute to disease …

Streptococcus pyogenes can cause a wide variety of acute infections throughout the body of
its human host. An underlying transcriptional regulatory network (TRN) is responsible for …

Streptococcus pyogenes [group A streptococcus (GAS)] is a human pathogen capable of
infecting diverse tissues. To successfully infect these sites, GAS must detect available …

For many years, Streptococcus anginosus has been considered a commensal colonizing the
oral cavity, as well as the gastrointestinal and genitourinary tracts. However, recent …

The ability of Enterococcus faecalis to colonize host anatomical sites is dependent on its
adaptive response to host conditions. Three glycosyl hydrolase gene clusters, each …

Quorum sensing (QS), an integral component of bacterial communication, is essential in
coordinating the collective response of diverse bacterial pathogens. Central carbon …

Catabolite control protein A (CcpA) is a master regulator of carbon source utilization and
contributes to the virulence of numerous medically important Gram‐positive bacteria. Most …