The elemental role of iron in DNA synthesis and repair

S Puig, L Ramos-Alonso, AM Romero… - Metallomics, 2017 - academic.oup.com
Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases …

[HTML][HTML] Direct electrochemistry of redox enzymes as a tool for mechanistic studies

C Léger, P Bertrand - Chemical Reviews, 2008 - ACS Publications
This review regards the use of dynamic electrochemistry to study the mechanism of redox
enzymes, with exclusive emphasis on the configuration where the protein is adsorbed onto …

An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and-unwinding activities

N Maio, MK Raza, Y Li, DL Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …

Electronic signature of DNA nucleotides via transverse transport

M Zwolak, M Di Ventra - Nano letters, 2005 - ACS Publications
We report theoretical studies of charge transport in single-stranded DNA in the direction
perpendicular to the backbone axis. We find that, if the electrodes which sandwich the DNA …

[PDF][PDF] DNA charge transport: From chemical principles to the cell

AR Arnold, MA Grodick, JK Barton - Cell chemical biology, 2016 - cell.com
The DNA double helix has captured the imagination of many, bringing it to the forefront of
biological research. DNA has unique features that extend our interest into areas of …

An introduction to electrochemical DNA biosensors

KJ Odenthal, JJ Gooding - Analyst, 2007 - pubs.rsc.org
Electrochemical DNAbiosensors exploit the affinity of single-stranded DNA for
complementary strands of DNA and are used in the detection of specific sequences of DNA …

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

N Maio, BAP Lafont, D Sil, Y Li, JM Bollinger Jr… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-
19, uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and …

Iron–sulfur proteins in health and disease

A Sheftel, O Stehling, R Lill - Trends in Endocrinology & Metabolism, 2010 - cell.com
Iron–sulfur (Fe/S) proteins are a class of ubiquitous components that assist in vital and
diverse biochemical tasks in virtually every living cell. These tasks include respiration, iron …

Recent advances in the structural mechanisms of DNA glycosylases

SC Brooks, S Adhikary, EH Rubinson… - Biochimica et Biophysica …, 2013 - Elsevier
DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …

Alkanethiol monolayer end groups affect the long-term operational stability and signaling of electrochemical, aptamer-based sensors in biological fluids

A Shaver, SD Curtis… - ACS applied materials & …, 2020 - ACS Publications
Electrochemical aptamer-based (E-AB) sensors achieve highly precise measurements of
specific molecular targets in untreated biological fluids. This unique ability, together with …