The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

Implantation of the blastocyst is a developmental milestone in mammalian embryonic
development. At this time, a coordinated program of lineage diversification, cell-fate …

Remodelling of the human embryo at implantation is indispensable for successful
pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

Measuring gene expression in individual cells is crucial for understanding the gene
regulatory network controlling human embryonic development. Here we apply single-cell …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

Abstract Development of the asymmetric amniotic sac—with the embryonic disc and
amniotic ectoderm occupying opposite poles—is a vital milestone during human embryo …