Aortic aneurysms, including thoracic aortic aneurysms and abdominal aortic aneurysms, are
life-threatening macrovascular diseases with high mortality. The already known key …

Objective: There are no current effective abdominal aortic aneurysm (AAA) drug therapies.
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …

The receptor interacting protein kinases 1/3 (RIPK1/3) have emerged as the key mediators
in cell death pathways and inflammatory signaling, whose ubiquitination, phosphorylation …

PANoptosis is a unique innate immune inflammatory lytic cell death pathway initiated by an
innate immune sensor and driven by caspases and RIPKs. As a distinct pathway, the …

Receptor-interacting protein kinase 3 executes a form of regulated necrosis called
necroptosis. Upon induction of an altered conformation by chemical inhibitors or via …

Objective and design The age-associated increases in aseptic inflammation and necroptosis
are closely related to the emergence of various age-associated diseases. Methods In this …

Somatic stem cells expand massively during tissue regeneration, which might require
control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How …

Regulated cell death (RCD) is a complex process that involves several cell types and plays
a crucial role in vascular diseases. Vascular smooth muscle cells (VSMCs) are the …

Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal
disease, has complex pathogenic mechanisms and few effective clinical therapies. DKD …

Background: Abnormalities in regulated cell death (RCD) are involved in multiple diseases.
However, the role of RCD in intracranial aneurysms (IA) remains unknown. The aim of this …