Immunotherapy has the potential to improve clinical outcomes with little toxicity for pediatric
patients with brain tumors. We conducted a pilot feasibility study of tumor lysate-pulsed …

Background aims Dendritic cells are regarded as the most effective antigen presenting cells
and coordinators of the immune response and therefore suitable as vaccine basis. Here we …

The family of mammalian chitinases includes members both with and without
glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is …

The ability of cancer immunotherapy to generate lasting responses in a broad spectrum of
tumors has generated great enthusiasm in medical oncology. A number of new immune …

Background Therapeutic cancer vaccination is an area of interest, even though promising
efficacy has not been demonstrated so far. Design A systematic review and meta-analysis …

The treatment of cancer by chemotherapy causes tumour cell death, mostly by apoptosis.
This tumour cell death may or may not elicit an immune response. At least in some cases …

Cancer vaccines offer the potential to enhance T cell-mediated antitumor immunity by
expanding and increasing the function of tumor-specific T cells and shaping the recall …

Abstract According to the International Agency for Research on Cancer, breast cancer is
more common than lung cancer globally. By 2040, mortality from breast cancer will rise by …

Vaccine‐induced p53‐specific immune responses were previously reported to be
associated with improved response to secondary chemotherapy in patients with small cell …

Purpose A wealth of preclinical information, as well as a modest amount of clinical
information, indicates that dendritic cell vaccines have therapeutic potential. The aim of this …