Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors

D Gulen, F Abe, S Maas, E Reed, K Cowan… - International …, 2008 - Elsevier
Anticancer immunotherapy using dendritic cell (DC) based vaccines provides an adjuvant
therapeutic strategy that is not cross reactive with conventional therapeutics. However …

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies

D Li, C Bentley, J Yates, M Salimi, J Greig, S Wiblin… - PLoS …, 2017 - journals.plos.org
Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among
the most effective classes of novel immunotherapies. However, the majority of human …

[HTML][HTML] 乳腺癌免疫治疗新策略

虞林玉, 李慕鹏, 旷达彬, 张聪敏, 陈小平 - 2016 - html.rhhz.net
乳腺癌是女性最常见的恶性肿瘤, 目前乳腺癌治疗以包括手术治疗, 化疗, 放疗, 内分泌治疗,
靶向治疗在内的综合治疗为主. 随着细胞生物学, 分子生物学, 免疫学的发展 …

Assessing the impact of the addition of dendritic cell vaccination to neoadjuvant chemotherapy in breast cancer patients: A model‐based characterization approach

BP Solans, A López‐Díaz de Cerio… - British Journal of …, 2019 - Wiley Online Library
Aims: Immunotherapy is a rising alternative to traditional treatment in breast cancer (BC)
patients in order to transform cold into hot immune enriched tumours and improve responses …

CD8 T-cell responses against cyclin B1 in breast cancer patients with tumors overexpressing p53

RB Sørensen, RS Andersen, IM Svane… - Clinical Cancer …, 2009 - AACR
Purpose: This study aimed to examine CD8 T-cell reactivity in breast cancer patients against
cyclin B1–derived peptides restricted by the human leukocyte antigen (HLA)-A2 molecule …

T cells reactive with HLA‐A* 0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients

JA Coleman, I Correa, L Cooper… - … journal of cancer, 2011 - Wiley Online Library
The nuclear protein PLU‐1/JARID1B/KDM5 is widely expressed in breast cancers while
showing highly restricted expression in normal adult tissues. To investigate whether …

暴发性急性胰腺炎早期感染特点分析

黄洁, 毛恩强 - 上海交通大学学报(医学版), 2010 - xuebao.shsmu.edu.cn
目的探讨暴发性急性胰腺炎(FAP) 患者早期感染的临床和细菌学特点. 方法回顾性分析82
例外科重症监护病房收治的FAP 患者的病史资料, 比较发病14 d 内继发感染患者(早期感染组 …

Immunity to Growth Factor Receptor–Bound Protein 10, a Signal Transduction Molecule, Inhibits the Growth of Breast Cancer in Mice

IS O-Sullivan, A Chopra, J Carr, TS Kim, EP Cohen - Cancer Research, 2008 - AACR
This study describes the application of a unique strategy to identify breast cancer antigens
[tumor-associated antigen (TAA)]. In a mouse model, the strategy led to the identification of …

[PDF][PDF] CTL 表位多肽疫苗抗肿瘤研究进展

陈婷, 汤旭东, 万瑛, 房殿春, 杨仕明 - 实用临床医药杂志, 2008 - jcmp.yzu.edu.cn
以肿瘤的免疫治疗为主的肿瘤生物治疗是目前临床治疗恶性肿瘤继手术, 放, 化疗之后的第4
种模式⋯ 1, 它既可以独立地治疗肿瘤, 又可与手术及放, 化疗结合, 具有疗效高, 特异性强 …

Addition of TAT protein transduction domain and GrpE to human p53 provides soluble fusion proteins that can be transduced into dendritic cells and elicit p53‐specific …

S Justesen, S Buus, MH Claesson, AE Pedersen - Immunology, 2007 - Wiley Online Library
The protein p53 has been shown to be an efficient tumour antigen in both murine and
human cancer vaccine studies and cancer vaccines targeting p53 based on major …