Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K+ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic …

PE MacDonald, AMF Salapatek, MB Wheeler - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) acts through its G-protein-coupled receptor to enhance
glucose-stimulated insulin secretion from pancreatic β-cells. This is believed to result from …

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence

MA Abdalla, H Deshmukh, S Atkin… - … in endocrinology and …, 2021 - journals.sagepub.com
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects
women of reproductive age. Metabolic consequences associated with PCOS include, but …

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice

A Maida, JA Lovshin, LL Baggio, DJ Drucker - Endocrinology, 2008 - academic.oup.com
The proglucagon gene gives rise to multiple peptides that play diverse roles in the control of
energy intake, gut motility, and nutrient disposal. Glucagon-like peptide-1 (GLP-1), a 30 …

[HTML][HTML] Dietary starch type affects body weight and glycemic control in freely fed but not energy-restricted obese rats

AA Aziz, LS Kenney, B Goulet, ES Abdel-Aal - The Journal of nutrition, 2009 - Elsevier
This study comprised 2 experiments that tested the hypothesis that a high-amylose starch
diet (AMO) would improve body weight and glycemic control relative to a high-amylopectin …

[HTML][HTML] Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis

B Gupta, Y Liu, DM Chopyk, RP Rai… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
There is compelling evidence implicating intestinal permeability in the pathogenesis of
nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly …

Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling

J Lovshin, J Estall, B Yusta, TJ Brown… - Journal of Biological …, 2001 - ASBMB
Glucagon-like peptide-2 (GLP-2) regulates energy homeostasis via effects on nutrient
absorption and maintenance of gut mucosal epithelial integrity. The biological actions of …

The glucagon-like peptides: a double-edged therapeutic sword?

TA Perry, NH Greig - Trends in pharmacological sciences, 2003 - cell.com
Abstract Glucagon-like peptide-1 (7–36)-amide (GLP-1) is an endogenous peptide that is
secreted from the gut in response to the presence of food. Recent studies have established …

Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling …

PE MacDonald, X Wang, F Xia, W El-Kholy… - Journal of Biological …, 2003 - ASBMB
Antagonism of voltage-dependent K+(Kv) currents in pancreatic β-cells may contribute to the
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and …

ß‐cell function and anti‐diabetic pharmacotherapy

S Del Prato, C Bianchi… - … /metabolism research and …, 2007 - Wiley Online Library
Type 2 diabetes is a chronic disease characterized by progressive worsening of glycaemic
control as indicated by the United Kingdom Prospective Diabetes Study (UKPDS). The …

Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

CK Katashima, VR Silva, TL Gomes, C Pichard… - Obesity …, 2017 - Wiley Online Library
This systematic review aimed at addressing the ursolic acid actions as an adjunctive
treatment of the obesity‐mediated metabolic abnormalities. To explore our aims, we used …