Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K+ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic …
PE MacDonald, AMF Salapatek, MB Wheeler - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) acts through its G-protein-coupled receptor to enhance
glucose-stimulated insulin secretion from pancreatic β-cells. This is believed to result from …
glucose-stimulated insulin secretion from pancreatic β-cells. This is believed to result from …
The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence
MA Abdalla, H Deshmukh, S Atkin… - … in endocrinology and …, 2021 - journals.sagepub.com
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects
women of reproductive age. Metabolic consequences associated with PCOS include, but …
women of reproductive age. Metabolic consequences associated with PCOS include, but …
The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice
The proglucagon gene gives rise to multiple peptides that play diverse roles in the control of
energy intake, gut motility, and nutrient disposal. Glucagon-like peptide-1 (GLP-1), a 30 …
energy intake, gut motility, and nutrient disposal. Glucagon-like peptide-1 (GLP-1), a 30 …
[HTML][HTML] Dietary starch type affects body weight and glycemic control in freely fed but not energy-restricted obese rats
AA Aziz, LS Kenney, B Goulet, ES Abdel-Aal - The Journal of nutrition, 2009 - Elsevier
This study comprised 2 experiments that tested the hypothesis that a high-amylose starch
diet (AMO) would improve body weight and glycemic control relative to a high-amylopectin …
diet (AMO) would improve body weight and glycemic control relative to a high-amylopectin …
[HTML][HTML] Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis
There is compelling evidence implicating intestinal permeability in the pathogenesis of
nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly …
nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly …
Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling
Glucagon-like peptide-2 (GLP-2) regulates energy homeostasis via effects on nutrient
absorption and maintenance of gut mucosal epithelial integrity. The biological actions of …
absorption and maintenance of gut mucosal epithelial integrity. The biological actions of …
The glucagon-like peptides: a double-edged therapeutic sword?
TA Perry, NH Greig - Trends in pharmacological sciences, 2003 - cell.com
Abstract Glucagon-like peptide-1 (7–36)-amide (GLP-1) is an endogenous peptide that is
secreted from the gut in response to the presence of food. Recent studies have established …
secreted from the gut in response to the presence of food. Recent studies have established …
Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling …
PE MacDonald, X Wang, F Xia, W El-Kholy… - Journal of Biological …, 2003 - ASBMB
Antagonism of voltage-dependent K+(Kv) currents in pancreatic β-cells may contribute to the
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and …
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and …
ß‐cell function and anti‐diabetic pharmacotherapy
S Del Prato, C Bianchi… - … /metabolism research and …, 2007 - Wiley Online Library
Type 2 diabetes is a chronic disease characterized by progressive worsening of glycaemic
control as indicated by the United Kingdom Prospective Diabetes Study (UKPDS). The …
control as indicated by the United Kingdom Prospective Diabetes Study (UKPDS). The …
Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review
CK Katashima, VR Silva, TL Gomes, C Pichard… - Obesity …, 2017 - Wiley Online Library
This systematic review aimed at addressing the ursolic acid actions as an adjunctive
treatment of the obesity‐mediated metabolic abnormalities. To explore our aims, we used …
treatment of the obesity‐mediated metabolic abnormalities. To explore our aims, we used …