Gene expression profiling shows that, by gene signature, the difference between BRAF-
positive and BRAF-negative PTC is so distinct that BRAF-positive cancer may be regarded …

Background: Thyroid surgery is the mainstay of treatment for thyroid cancer, but there are
options for the surgical approach. There is a general agreement that the goal of thyroid …

Introduction Prognosis of thyroid cancer is strictly related to loco-regional metastases.
Cervical lymphadenectomy has a specific oncologic role but may lead to significant increase …

Background The purpose of this study was to evaluate the frequency and pattern of central
lymph node metastasis in isthmic papillary thyroid carcinoma (PTC). Methods We compared …

Papillary thyroid carcinoma (PTC) generally has a good prognosis, but disease recurs in
25% to 30% of PTC patients and significantly reduces the survival rate. Lymph node …

Over the last decade, investigators have developed a clearer understanding of the genetic
alterations underlying thyroid carcinogenesis. A number of biomarkers involved in the …

Background: The clinical evaluation of enlarged local lymph nodes (LNs) is difficult at the
beginning and throughout the follow-up of differentiated thyroid carcinoma (DTC). Although …

Purpose Sentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma
(PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged …

Background The aims of this study were to evaluate the rate and risk factors of ipsilateral
and contralateral central lymph node (CLN) metastases in patients with papillary thyroid …

Background Lateral lymph node metastasis is an important prognostic factor and is
predictive of tumor recurrence and cause-specific survival in patients with papillary thyroid …