Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

In addition to their pivotal role in thrombosis and wound repair, platelets participate in
inflammatory responses. We investigated the role of platelets in the autoimmune disease …

Platelets contribute to processes beyond thrombus formation and may play a so far
underestimated role as an immune cell in various circumstances. This review outlines …

Platelet adhesion, activation and aggregation on the exposed subendothelial extracellular
matrix (ECM) are essential for haemostasis, but may also lead to occlusion of diseased …

Platelets are chief effector cells in hemostasis. In addition, however, their specializations
include activities and intercellular interactions that make them key effectors in inflammation …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body.
Collagens are not only essential for the mechanical stability of tissues, but are also …