Novel approaches to target the microenvironment of bone metastasis
Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …
and prostate cancers, the most common malignancies in women and men, respectively …
[HTML][HTML] FUT8 alpha-(1, 6)-fucosyltransferase in cancer
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …
tumour progression from malignant transformation to metastasis and immune evasion. One …
[HTML][HTML] Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma
Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …
modifications. These modifications are not directly encoded in the genomic template but …
[HTML][HTML] Aberrant glycosylation and cancer biomarker discovery: a promising and thorny journey
M Wang, J Zhu, DM Lubman, C Gao - Clinical Chemistry and …, 2019 - degruyter.com
Glycosylation is among the most important post-translational modifications for proteins and
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …
[HTML][HTML] The diverse contributions of fucose linkages in cancer
Fucosylation is a post-translational modification of glycans, proteins, and lipids that is
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …
[HTML][HTML] Glycans as biomarkers in prostate cancer
Prostate cancer is the most commonly diagnosed malignancy in men, claiming over 350,000
lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA) testing …
lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA) testing …
[HTML][HTML] Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins
in physiological and pathological processes. However, quantitative characterization of core …
in physiological and pathological processes. However, quantitative characterization of core …
Protein glycosylation in extracellular vesicles: Structural characterization and biological functions
J Macedo-da-Silva, VF Santiago… - Molecular …, 2021 - Elsevier
Extracellular vesicles (EVs) are lipid bilayer-enclosed particles involved in intercellular
communication, delivery of biomolecules from donor to recipient cells, cellular disposal and …
communication, delivery of biomolecules from donor to recipient cells, cellular disposal and …
N‐glycosylation of PD‐1 promotes binding of camrelizumab
K Liu, S Tan, W Jin, J Guan, Q Wang, H Sun, J Qi… - EMBO …, 2020 - embopress.org
PD‐1 is a highly glycosylated inhibitory receptor expressed mainly on T cells. Targeting of
PD‐1 with monoclonal antibodies (MA bs) to block the interaction with its ligand PD‐L1 has …
PD‐1 with monoclonal antibodies (MA bs) to block the interaction with its ligand PD‐L1 has …