Hierarchically structured polymer fibers encompassing 1-D, 2-D, and 3-D structures with at
least one dimension nano-to micro-meters in size have recently received an increasing …

Heart failure (HF) affects 60 million people worldwide and has developed into a global
public health problem surpassing cancer and urgently needs to be solved. According to the …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …

Background: The adult mammalian heart has limited ability to repair itself after injury.
Zebrafish, newts, and neonatal mice can regenerate cardiac tissue, largely by cardiac …

Cardiac regeneration is a rapidly evolving and controversial field of research. The
identification some 12 years ago of progenitor cells that reside within the heart spurred …

In dramatic contrast to the poor repair outcomes for humans and rodent models such as
mice, salamanders and some fish species are able to completely regenerate heart tissue …

Abstract microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into
induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration …

Fabrication of tissue engineering scaffolds with the use of novel 3D printing has gained lot of
attention, however systematic investigation of biomaterials for 3D printing have not been …

Autophagy is a ubiquitous cellular catabolic process responsive to energy stress. Research
over the past decade has revealed that cardiomyocyte autophagy is a prominent …

The ability to manipulate cellular organization within soft materials has important potential in
biomedicine and regenerative medicine; however, it often requires complex fabrication …