Non-alcoholic fatty liver disease–a global public health perspective

ZM Younossi - Journal of hepatology, 2019 - Elsevier
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases

N Chalasani, Z Younossi, JE Lavine, M Charlton… - Hepatology, 2018 - journals.lww.com
This guidance provides a data‐supported approach to the diagnostic, therapeutic, and
preventive aspects of nonalcoholic fatty liver disease (NAFLD) care. A “Guidance” document …

Molecular pathways of nonalcoholic fatty liver disease development and progression

F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent

RM Mancina, P Dongiovanni, S Petta, P Pingitore… - Gastroenterology, 2016 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver
damage and is characterized by steatosis. Genetic factors increase risk for progressive …

Epidemiology and natural history of non-alcoholic fatty liver disease

Y Fazel, AB Koenig, M Sayiner, ZD Goodman… - Metabolism, 2016 - Elsevier
Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver
disease (NAFLD) that leads to progressive liver disease and presents a growing challenge …

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

A Lonardo, S Bellentani, CK Argo, S Ballestri… - Digestive and Liver …, 2015 - Elsevier
An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to
identification of individuals at high risk of developing chronic liver disease and extra-hepatic …

Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of
chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the …

[PDF][PDF] Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

P Dongiovanni, S Petta, C Maglio, AL Fracanzani… - …, 2015 - Wiley Online Library
Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic
steatohepatitis (NASH) may progress to fibrosis and promote atherosclerosis. Carriers of the …

Statin use and non-alcoholic steatohepatitis in at risk individuals

P Dongiovanni, S Petta, V Mannisto, RM Mancina… - Journal of …, 2015 - Elsevier
Background & Aims Excess hepatic free cholesterol contributes to the pathogenesis of non-
alcoholic steatohepatitis, and statins reduce cholesterol synthesis. Aim of this study was to …