The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

Regular physical activity is associated with lower cancer incidence and mortality, as well as
with a lower rate of tumour recurrence. The epidemiological evidence is supported by …

Blockade of immune checkpoints has transformed the therapy of several cancers. However,
immune‐related adverse events (irAEs) have emerged as a major challenge limiting the …

In the tumor milieu of head and neck squamous cell carcinoma (HNSCC), distinct B cell
subpopulations are present, which exert either pro-or anti-tumor activities. Multiple factors …

B lymphocytes are essential mediators of humoral immunity and play multiple roles in
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …

Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function
similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an …

Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that
resembles that of secondary lymphoid organs. Both structures share common …

To mount an effective anti-tumor immune response capable of controlling or eliminating
disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and …

It is widely recognized that tumor immune microenvironment (TIME) plays a crucial role in
tumor progression, metastasis, and therapeutic response. Despite several noninvasive …

Hormone receptor-positive breast cancer (HR+ BC) is known to be relatively insensitive to
chemotherapy, and since chemotherapy has remained the major neoadjuvant therapy for …